1. Mandatory Disciplines (2 credit units, 30 credit hours)
Syllabus: Training course for graduate students, which allows the student to acquire experience in teaching, preparing, planning and teaching theoretical and practical classes in disciplines at the undergraduate level of the courses of Medicine, Nursing, Pharmacy, Dentistry, Biological Sciences and Nutrition under the supervision and monitoring of the teacher responsible for the discipline.
SCIENTIFIC RESEARCH METHODOLOGY
Syllabus: Historical-philosophical approach to the issue of science and method; Theoretical aspects related to the scientific production process and its relationship with environmental technology; Elements for organizing scientific works including those related to the conclusion of a graduate course; Guidance for the development of the research process with regard to problem definition, sample universe, data collection and analysis, ABNT standards; Specificity of experiments / tests.
TECHNOLOGICAL INNOVATION IN HUMAN DEVELOPMENT
Syllabus: Promote an understanding of the process of technological innovation in general, and in the fields of health in particular; Understand the role of technological innovation in the context of globalization of markets; Discuss techniques and instruments through which the innovation process can be promoted and managed by the company, the state and the university; Sensitize participants to the importance of articulation and cooperation from different fields of knowledge for the development of innovation, in general, and health innovation, in particular. Discussion of the ways of inserting such questions in the context of teaching, so that this too can be contributing as an agent for transforming reality. Patents and technological innovation.
Syllabus: Historical aspects of the development of Bioactive Molecules, with an emphasis on products of natural origin. Main aspects that correlate chemical structure with biological activity, providing basic pharmacology subsidies. Strategies applied in the development of Bioactive Molecules, giving examples of the main therapeutic classes.
2. Mandatory disciplines (4 credit units, 60 credit hours)
Syllabus: Nature of statistical methods. Samples. Calculation of probabilities and frequency distribution. Hypothesis tests. Regression. Student's t test. Chi-Square. Analysis of variance and covariance. Contingency table. Non-parametric methods. Statistics as a necessary instrument of the scientific method in the medical-biological field.
3. Elective Disciplines (2 credit units, 30 credit hours)
BASIC NOTIONS OF BIOETHICS APPLIED TO RESEARCH
Syllabus: Aims to guide graduate students towards ethical reflection in science, focusing on the emergence of Bioethics and related historical facts; educate for the practice of good science, without fraud, falsification or plagiarism; provides ethical foundations for research with humans and animals; highlight the ethical values pertinent to the adequate planning of research projects aimed at valuing integrity and scientific honesty, and bringing to the graduate students elements for self-criticism and improvement of their own research project, from the bioethical point of view.
Syllabus: Presentation of topics of the student's choice related to his dissertation or thesis, in the form of two seminars; one specifically and the other associative with other areas of health sciences
EXPERIMENT PLANNING AND OPTIMIZATION
Syllabus: Importance of strategic planning. Methodologies and Techniques. Simplified models. Observation and reports. Factorial planning. Odds. Hypothesis testing. Minimization of errors in experiments.
Syllabus: Epigenetics refers to the number of changes in the chromatin structure that affect the expression of the gene, without changing the primary DNA sequence, and these changes lead to the activation of gene transcription or silencing. Several studies have shown that epigenetic changes contribute significantly to the development and progression of tumors. Over the years, the study of epigenetic processes has increased, and new therapeutic approaches have emerged. This course will address the main epigenetic mechanisms recently described in carcinogenesis, including aberrant DNA methylation, histone modifications (histone methylation and acetylation) and miRNAs. The clinical implications of these epigenetic changes and the use of drugs acting on the epigenome will also be discussed.
PHARMACOLOGY AND TOXICOLOGY OF FREE RADICALS
Syllabus: Free radicals: sources, classification, formation, biological effects and oxidative damage. Chemical structure, mechanisms and chemical reactivity. Biochemistry of free radicals. Diseases and therapeutic applications. Antioxidant defense system. Antioxidants and pro oxidants. Free radicals as inducers of cell death.
4. Elective Disciplines (3 credit units, 45 credit hours)
ELECTRONIC STRUCTURE APPLIED TO SPECTROSCOPY
Syllabus: Electronic structure programs. Molecules design. Fundamentals of group theory. Fundamentals of DFT. Post-Hartree-Fock methods. Dichroism (VCD). NMR. Absorption and emission. Infra-red (IR). Raman. Ultraviolet. XPS.
5. Elective Disciplines (4 credit units, 60 credit hours)
Syllabus: Principles of molecular and cellular pharmacology. Pharmacology of natural and synthetic substances. Elucidation of molecular mechanisms of signaling in neurons and cells of the immune system, fungi and bacteria, including the modulation of synaptic function, sensory transduction and inflammatory response, and the role of these mechanisms in pathological conditions. Ionotropic receptors in the study of signaling mediated by nicotinic receptors of acetylcholine, glutamate, GABA, ATP and TRP channels, seeking new possibilities for pharmacological intervention in neuropsychiatric diseases such as Alzheimer's, Parkinson's, schizophrenia and epilepsy, and in lesions traumatic and ischemic neurological diseases, using electrophysiological, biochemical, morphological and molecular biology techniques, in vitro and in vivo
Syllabus: Molecular mechanisms in toxicology and intoxications. Molecular aspects in toxicokinetics and toxicodynamics. Evaluation of molecular and cellular toxicity. ADMET Aspects of Bioactive Molecules and Medicines. Drug interactions. Food toxicology, occupational toxicology, environmental toxicology, social toxicology, toxinology (poisonous animals) and toxicological analysis. Structure relationship and molecular toxicity.
SPECIAL TOPICS IN MOLECULAR MODELING
Syllabus: Systematic study under the interdisciplinary aspect in technological research in Molecular Modeling; Presentation and discussion of topics of interest to the course; Presentation of seminars by specialists in the areas of interest of the course; Presentation of individual seminars by students addressing topics related to the research to be developed; Individual seminars held by students to present the Research Project. Being complemented as a discipline related to new concepts, methodologies or approaches in the study area.
SPECIAL TOPICS IN MEDICAL CHEMISTRY
Syllabus: Systematic study under the interdisciplinary aspect in technological research in Medicinal Chemistry; Presentation and discussion of topics of interest to the course; Presentation of seminars by specialists in the areas of interest of the course; Presentation of individual seminars by students addressing topics related to the research to be developed; Individual seminars held by students to present the Research Project. Being complemented as a discipline related to new concepts, methodologies or approaches in the study area.
Syllabus: Introduction to Microbiology. Historic. Abiogenesis and Biogenesis. Microbial Theory of Disease. Classification of living beings. Eukaryotic and prokaryotic beings. Microbial control. Antimicrobials: selection and evaluation. Staining methods and microscopic preparations. Microorganism-plant / animal interactions. Biogeochemical cycles. Microbiology applications in biotechnology and the development of new antimicrobials
Syllabus: Fundamentals of pharmacological biochemistry. Biochemical principles of the action of representative drugs. Structure of functional molecules. Biochemical mechanisms. How drugs work in the physiological, pathological and structural context. Enzymes, pharmacodynamics, pharmacokinetics and drug metabolism. Biochemical pharmacology of cell excitation, hormones, nitric oxide, chemotherapy and others.
Syllabus: This course aims to introduce the student to the necessary knowledge to create and evaluate a quantitative relationship between biological activity and a set of descriptive parameters, in a homologous series of molecules. Hanch-Fujita model; FreeWilson model; QSAR-2D; QSAR-3D; QSAR applications; QSAR in non-specific toxicity; QSAR in mutagenesis, carcinogenesis and antitumor substances; QSAR of agents in the central nervous system; QSAR in pesticides
Syllabus: Historical aspects of the development of Bioactive Molecules, with an emphasis on products of natural origin. Main aspects that correlate the chemical structure with the biological activity, providing the basic subsidies of pharmacology. Strategies applied in the development of Bioactive Molecules, giving examples of the main therapeutic classes.
METHODS AND TECHNIQUES IN MOLECULAR BIOLOGY AND TOXICOLOGY
Syllabus: Methods and techniques adapted to specific projects such as: Molecular cloning; Enzymes for DNA manipulation; PCR; Agarose gel electrophoresis; Cloning of PCR products; Plasmids or vectors; Cell transformation; DNA extraction and purification; DNA sequencing; DNA and RNA analysis in blotting; Chromatographic methods; Protein purification.
Syllabus: Study of nematelminths, flatworms and protozoa that cause disease in humans; the main ectoparasitic arthropods that cause and transmit disease to humans; laboratory diagnostic techniques and their practical application and the study of endoparasite / ectoparasite and host interactions to understand the pathogenesis and pathology of the diseases caused by them. Biochemical targets and antiparasitic development.
ORGANIC PHYSICAL CHEMISTRY
Syllabus: Principles of Reactivity Models of Chemical Bonding; Introduction to chemical and thermodynamic kinetics. Reagents and reaction mechanisms. Correlation of Structure with Reactivity and Properties. Empirical bases. Experimental methods and data processing. Transition state theories. Effects of substituents on transition states. Solvent effects and reactions in solution. Structure and order in solvents. Hydrogen bond. Hydrophobic bond. Complex reactions. Acids and bases, electrophiles and nucleophiles. Isotopic effects on kinetics. Steric and conformational properties. Catalysis. Substitution reactions on carbon. Elimination reactions, polar addition, intramolecular and via free radicals. Organic Photochemistry. Detection and study of Reactive Intermediates.
INORGANIC STRUCTURAL CHEMISTRY
Syllabus: Solid State. Covalent bond. Experimental Methods for Determining Molecular Structure. Mechanisms of Inorganic Reactions. Descriptive Chemistry of Transition Metals. Introduction to Binders and Complexes. Coordination Chemistry. Organometallic Chemistry. Homogeneous Catalysis with Transition Metal Complexes. Chains, Rings, Polyhedra and Metal Clusters. Structure of bioactive inorganic compounds.
ORGANIC STRUCTURAL CHEMISTRY
Syllabus: Huckel molecular orbitals, calculation of coefficients and charges; cicloaddition reactions, sigmatropic rearrangement, electrocyclic reactions and secondary interactions; Acidity and basicity: Hammett and its applications; sigmas (+, I and R); protonic affinity, gas phase acidity, hardness and softness; isotopic kinetic effect; free radicals: Marcus theory, H abstraction, polymerization, rearrangements. The theoretical bases of the structural properties and chemical reactivity of bioactive organic compounds, through a functional / polyfunctional approach. Topics: Chemical properties and reactivity; solubility; acidity-basicity; chemical bonds / interactions; reactivity and properties of the main functional groups / functionalities of bioactive substances (alkyl, aryl, heteroaryl, halides, alcohols, ethers, phenols, amines, amides, carbonyls, carboxyls, sulfonyl, thio- and nitro-derivatives); stereo-electronic aspects of reactivity; mechanisms of biological reactions. Structure of bioactive organic compounds. Principles of biological chemistry.
MICROSCOPY AND ITS TECHNOLOGICAL APPLICATIONS IN STRUCTURAL BIOLOGY
Syllabus: Understand the fundamentals of light and electronic microscopies and their applications in almost all scientific specialties and technological applications. Students in the different fields of science knowledge must be well informed about the use and operation and the countless possibilities and limitations.